ADRP anticorps (AA 31-130)

N° du produit ABIN738606

Détail du produit anti-ADRP anticorps

Antigène: ADRP (PLIN2) (Perilipin 2 (PLIN2))

Épitope: AA 31-130

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris

Homologie: Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from rat ADFP

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-ADRP (ABIN738606)

Zhao, Han, Hong, Sun: "Adipose differentiation‑related protein knockdown inhibits vascular smooth muscle cell proliferation and migration and attenuates neointima formation." dans: Molecular medicine reports, Vol. 16, Issue 3, pp. 3079-3086, (2018) (PubMed).

Amrutkar, Cansby, Nuñez-Durán, Pirazzi, Ståhlman, Stenfeldt, Smith, Borén, Mahlapuu: "Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 4, pp. 1564-76, (2015) (PubMed).

Amrutkar, Cansby, Chursa, Nuñez-Durán, Chanclón, Ståhlman, Fridén, Mannerås-Holm, Wickman, Smith, Bäckhed, Borén, Howell, Mahlapuu: "Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model." dans: Diabetes, Vol. 64, Issue 8, pp. 2791-804, (2015) (PubMed).

Liu, Dai, Liu, Liu, Tang, Wang, Yi, Liu, Jiang, Yang, Yuan: "Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells." dans: Acta biochimica et biophysica Sinica, Vol. 42, Issue 9, pp. 635-45, (2010) (PubMed).

Détails sur ADRP

Antigène: ADRP (PLIN2) (Perilipin 2 (PLIN2))

Autre désignation: ADFP (PLIN2 Produits)

Synonymes: anticorps ADFP, anticorps ADRP, anticorps AA407157, anticorps ADPH, anticorps Adfp, anticorps Adrp, anticorps adfp, anticorps adrp, anticorps fatvg, anticorps MGC76047, anticorps adipophilin, anticorps PLIN2, anticorps DKFZp469F1012, anticorps perilipin-2, anticorps zgc:110411, anticorps perilipin 2, anticorps perilipin 2 L homeolog, anticorps adipophilin, anticorps perilipin-2, anticorps PLIN2, anticorps Plin2, anticorps plin2, anticorps plin2.L, anticorps LOC100304704, anticorps LOC100380740

Sujet:

Synonyms: ADFP, Adipophilin, Adipose dferentiation related protein, Adipose dferentiation-related protein, Perilipin-2, PLIN2, PLIN2_HUMAN, adipophilin, Adipose dferentiation related protein, ADRP, MGC10598

Background: Milk lipid globules from humans, cows and rats contain a protein identified as adipocyte differentiation-related protein (ADFP) associated with the globule surface membrane material. This protein, previously believed to be specific to adipocytes, was a major constituent of the globule surface and was present in a detergent-insoluble complex that contained stoichiometric amounts of butyrophilin and xanthine oxidase. ADFP (Adipophilin) occurs in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells. In tissues, however, expression of adipophilin is restricted to certain cell types, such as lactating mammary epithelial cells, adrenal cortex cells, Sertoli and Leydig cells of the male reproductive system, and steatosis or fatty change hepatocytes in alcoholic liver cirrhosis. ADFP may be a possible new marker for the identification of specialized differentiated cells containing lipid droplets and for diseases associated with fat-accumulating cells.

ID gène: 298199

Pathways: Regulation of Lipid Metabolism by PPARalpha, Lipid Metabolism