beta Catenin anticorps (AA 661-781)

N° du produit ABIN738621

Cet anticorps anti-beta Catenin est un anticorps Lapin Polyclonal détectant beta Catenin dans WB, FACS, IF (cc), ELISA, IF (p), IHC (p) et IHC (fro). Adapté pour Humain, Souris, Rat, Poisson zèbre (Danio rerio) et Porc. Ce Primary Antibody a été cité dans 8+ publications.

Aperçu rapide pour beta Catenin anticorps (AA 661-781) (ABIN738621)

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp beta Catenin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-beta Catenin anticorps

Épitope: AA 661-781

Réactivité croisée: Humain, Souris, Porc, Rat, Poisson zèbre (Danio rerio)

Homologie: Cow,Sheep,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Beta catenin

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-beta Catenin (ABIN738621)

Zhu, Shen, Xu, Chen, Huang: "Suppression of Wnt5a, but not Wnts, relieves chronic post-thoracotomy pain via anti-inflammatory modulation in rats." dans: Biochemical and biophysical research communications, Vol. 493, Issue 1, pp. 474-480, (2017) (PubMed).

Yang, Liu, Miao, Yang, Fu, Dou, Cai, Zong, Tan, Chen, Wang: "Induction of VEGFA and Snail-1 by meningitic Escherichia coli mediates disruption of the blood-brain barrier." dans: Oncotarget, Vol. 7, Issue 39, pp. 63839-63855, (2016) (PubMed).

Zheng, Liu, Li, Tang, Zhang, Tang: "Lithium posttreatment confers neuroprotection through glycogen synthase kinase-3β inhibition in intracerebral hemorrhage rats." dans: Journal of neurosurgery, pp. 1-9, (2016) (PubMed).

Qi, Li, Xu, Chang, Shu, Zhou: "Therapeutic role of human hepatocyte growth factor (HGF) in treating hair loss." dans: PeerJ, Vol. 4, pp. e2624, (2016) (PubMed).

Zhang, Shi, Song, Sun, Yang, Li: "BAMBI Promotes C2C12 Myogenic Differentiation by Enhancing Wnt/?-Catenin Signaling." dans: International journal of molecular sciences, Vol. 16, Issue 8, pp. 17734-45, (2015) (PubMed).

Lu, Duan, Zhang, Wu, Wang: "Expression of Wnt3a, Wnt10b, ?-catenin and DKK1 in periodontium during orthodontic tooth movement in rats." dans: Acta odontologica Scandinavica, pp. 1-7, (2015) (PubMed).

Hu, Meng, Yu, Hu, Mao: "Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth." dans: Oncotarget, Vol. 6, Issue 14, pp. 12174-87, (2015) (PubMed).

Lian, Duan, Wu, Li, Chen, Wang, Cai, Weng: "Expression and Clinical Significance of Von Hippel-Lindau Downstream Genes: Jade-1 and β-Catenin Related to Renal Cell Carcinoma." dans: Urology, (2012) (PubMed).

Détails sur beta Catenin

Antigène: beta Catenin (CATNB) (Catenin, beta (CATNB))

Autre désignation: Beta catenin

Sujet:

Synonyms: CTNNB, MRD19, armadillo, Catenin beta-1, Beta-catenin, CTNNB1, OK/SW-cl.35, PRO2286

Background: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.

ID gène: 1499

UniProt: P35222

Pathways: Peptide Hormone Metabolism