Integrin beta 3 anticorps (AA 27-120)

N° du produit ABIN739029

Cet anticorps anti-Integrin beta 3 est un anticorps Lapin Polyclonal détectant Integrin beta 3 dans WB, FACS, ELISA, IHC (fro), IHC (p), IF (cc) et IF (p). Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 6+ publications.

Aperçu rapide pour Integrin beta 3 anticorps (AA 27-120) (ABIN739029)

Antigène: Integrin beta 3 (ITGB3)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin beta 3 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Integrin beta 3 anticorps

Épitope: AA 27-120

Réactivité croisée: Humain, Souris

Homologie: Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Integrin beta 3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Integrin beta 3 (ABIN739029)

Ristori, Cicaloni, Salvini, Tinti, Tinti, Simons, Corti, Donnini, Ziche: "Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells." dans: Cells, Vol. 9, Issue 11, (2021) (PubMed).

Qu, Ming-Zhang, Yuan-Fang, Wang, Zhang: "Effect of 2,3',4,4',5-Pentachlorobiphenyl Exposure on Endometrial Receptivity and the Methylation of HOXA10." dans: Reproductive sciences (Thousand Oaks, Calif.), Vol. 25, Issue 2, pp. 256-268, (2017) (PubMed).

Zhang, Erfle, Harder, Beneke, Beil, Bulkescher, Rohr, Keese: "High-Throughput RNAi Screening Identifies a Role for the Osteopontin Pathway in Proliferation and Migration of Human Aortic Smooth Muscle Cells." dans: Cardiovascular drugs and therapy, Vol. 30, Issue 3, pp. 281-95, (2017) (PubMed).

Zhou, Qu, Sun, Wu, Liu, Yang, Zhang: "Sophoricoside fails the embryo implantation by compromising the uterine endometrial receptivity at implantation "window" of pregnant mice." dans: Chemico-biological interactions, Vol. 219C, pp. 57-63, (2014) (PubMed).

Wang, Jiang, Peng, Guo, Shang, Chen, Wu, Chen: "Induced apoptosis of osteoblasts proliferating on polyhydroxyalkanoates." dans: Biomaterials, Vol. 34, Issue 15, pp. 3737-46, (2013) (PubMed).

Li, Liu, Kan, Li, Liu, Lu: "Elevated expression of integrin αv and β5 subunit in laryngeal squamous-cell carcinoma associated with lymphatic metastasis and angiogenesis." dans: Pathology, research and practice, Vol. 209, Issue 2, pp. 105-9, (2013) (PubMed).

Détails sur Integrin beta 3

Antigène: Integrin beta 3 (ITGB3)

Autre désignation: Integrin beta 3

Sujet:

Synonyms: GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, Integrin beta-3, Platelet membrane glycoprotein IIIa, ITGB3

Background: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Poids moléculaire: 87kDa

ID gène: 3690

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex