Integrin beta 3 anticorps (AA 27-120) (PE)

N° du produit ABIN739039

Cet anticorps Lapin Polyclonal détecte spécifiquement Integrin beta 3 dans WB et FACS. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Integrin beta 3 anticorps (AA 27-120) (PE) (ABIN739039)

Antigène: Integrin beta 3 (ITGB3)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Integrin beta 3 est conjugé à/à la PE

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-Integrin beta 3 anticorps (PE)

Épitope: AA 27-120

Réactivité croisée: Humain, Souris

Homologie: Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Integrin beta 3

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Integrin beta 3

Antigène: Integrin beta 3 (ITGB3)

Autre désignation: Integrin beta 3

Sujet:

Synonyms: GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, Integrin beta-3, Platelet membrane glycoprotein IIIa, ITGB3

Background: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

ID gène: 3690

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex