tau anticorps (pSer579)

N° du produit ABIN739620

Cet anticorps anti-tau est un anticorps Lapin Polyclonal détectant tau dans WB, IF (p) et IHC (p). Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien et Poulet. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour tau anticorps (pSer579) (ABIN739620)

Antigène: tau (tau Protein)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp tau est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-tau anticorps

Épitope: pSer579

Réactivité croisée: Boeuf (Vache), Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human Tau protein isoform 2 around the phosphorylation site of Ser579

Isotype: IgG

Information d'application

Indications d'application: WB (1:100-500),IHC-P (1:100-500),IF (p) (1:100-500)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Références pour anticorps anti-tau (ABIN739620)

Cai, Yan, Wang: "Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder." dans: Clinical interventions in aging, Vol. 8, pp. 1089-95, (2013) (PubMed).

Détails sur tau

Antigène: tau (tau Protein)

Sujet:

Synonyms: TauSer404, MAPT, Microtuble-associted protein Tau, AI413597, AW045860, DDPAC, Disinhibition dementia parkinsonism amyotrophy complex, FLJ31424, FTDP 17, FTDP17, G Protein beta 1 gamma 2 subunit interacting factor 1, G protein beta1/gamma2 subunit interacting factor 1, MAPTL, MGC134287, MGC138549, MGC156663, Microtubule associated protein tau isoform 4, MSTD, Mtapt, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament tau, PHF tau, PHF-tau, PPND, pTau, RNPTAU, Tauopathy and respiratory failure, included, TAU_HUMAN.

Background: Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Poids moléculaire: 49kDa

ID gène: 4137