AXIN2 anticorps (AA 86-812)

N° du produit ABIN7825283

Cet anticorps anti-AXIN2 est un anticorps Lapin Polyclonal détectant AXIN2 dans IHC. Adapté pour Poisson zèbre (Danio rerio).

Aperçu rapide pour AXIN2 anticorps (AA 86-812) (ABIN7825283)

Antigène: AXIN2 (Axin 2 (AXIN2))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AXIN2 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-AXIN2 anticorps

Épitope: AA 86-812

Fonction: Anti-Zebrafish AXIN2 Antibody

Attributs du produit: Anti-Zebrafish AXIN2 Antibody catalog #AZP57095. Tested in IHC applications. This antibody reacts with Zebrafish.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived zebrafish AXIN2 recombinant protein (Position: H86-D812)

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry, 2-5 μg/mL, Zebrafish

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur AXIN2

Antigène: AXIN2 (Axin 2 (AXIN2))

Autre désignation: AXIN2

Sujet: Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene. The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

UniProt: P57095

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling