Recombinant CHD1 anticorps

N° du produit ABIN7828112

L’anticorps anti-CHD1 Monoclonal Lapin est utilisé pour la détection de CHD1 dans des échantillons de Humain et Souris. Il a été validé pour WB.

Aperçu rapide pour Recombinant CHD1 anticorps (ABIN7828112)

Antigène: CHD1 (Chromodomain Helicase DNA Binding Protein 1 (CHD1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CHD1 est non-conjugé

Application: Western Blotting (WB)

Clone: A646

Détail du produit anti-CHD1 anticorps

Fonction: Recombinant CHD1 Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human CHD1 fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur CHD1

Antigène: CHD1 (Chromodomain Helicase DNA Binding Protein 1 (CHD1))

Autre désignation: CHD1

Sujet: CHD,chromodomain-helicase-DNA-binding protein,CHD1,chromodomain-helicase-DNA-binding protein 1,CHD1 belongs to the SNF2/RAD54 helicase family. CHD1 is an aTP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. CHD1 regulates polymerase II transcription. It is required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. CHD1 negatively regulates DNA replication. CHD1 is associated with histone deacetylase (HDAC) activity. CHD1 is required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. It functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. It is required for maintaining open chromatin and pluripotency in embryonic stem cells. In PTEN-deficient prostate and breast cancers, CHD1 depletion profoundly and specifically suppressed cell proliferation, cell survival and tumorigenic potential. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 197 kDa

Observed MW: 250 kDa The actual band is not consistent with the expectation.

UniProt: O14646

Pathways: Chromatin Binding