Recombinant EIF3G anticorps

N° du produit ABIN7828189

Cet anticorps Lapin Monoclonal détecte spécifiquement EIF3G dans WB, IHC, IF et FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant EIF3G anticorps (ABIN7828189)

Antigène: EIF3G (Eukaryotic Translation Initiation Factor 3, Subunit G (EIF3G))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp EIF3G est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: A689

Détail du produit anti-EIF3G anticorps

Fonction: Recombinant eIF3G Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000-1:2000,IHC 1:50-1:100,IF 1:50-1:100,FCM 1:50

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur EIF3G

Antigène: EIF3G (Eukaryotic Translation Initiation Factor 3, Subunit G (EIF3G))

Autre désignation: eIF3G

Sujet: EIF3S,EIF3G,EIF3-P42,EIF3S4,eIF3-delta,eIF3-p44,eIF3 is a large translation initiation complex with 10 to 13 different subunits. eIF3A, eIF3B, eIF3C, eIF3E, eIF3F, and eIF3H are the core subunits critical for the function of this complex. eIF3 physically interacts with eIF4G, which may be responsible for the association of the 40S ribosomal subunit with mRNA. eIF3 also stabilizes the binding of Met-tRNAf.eIF2.GTP to the 40S ribosomal subunit and helps keep the integrity of the resulting complex upon addition of the 60S ribosomal subunit. Studies have shown that mTOR interacts with eIF3 directly. When cells are stimulated by hormones or mitogenic signals, mTOR binds to the eIF3 complex and phosphorylates S6K1. This process results in the dissociation of S6K1 from eIF3 and S6K1 activation. The activated S6K1 then phosphorylates its downstream targets including ribosomal protein S6 and eIF4B, resulting in stimulation of translation. Further findings demonstrated that activated mTOR signaling induces the association of eIF3 with eIF4G upon stimulation with insulin. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 36 kDa

Observed MW: 40 kDa The actual band is not consistent with the expectation.

UniProt: O75821

Pathways: Ribonucleoprotein Complex Subunit Organization