Recombinant INPPL1 anticorps

N° du produit ABIN7828310

L’anticorps anti-INPPL1 Monoclonal Lapin est utilisé pour la détection de INPPL1 dans des échantillons de Humain. Il a été validé pour WB, IHC et IF.

Aperçu rapide pour Recombinant INPPL1 anticorps (ABIN7828310)

Antigène: INPPL1 (Inositol Polyphosphate Phosphatase-Like 1 (INPPL1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp INPPL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A749

Détail du produit anti-INPPL1 anticorps

Fonction: Recombinant SHIP-2 Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000,IHC 1:100,IF 1:50

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur INPPL1

Antigène: INPPL1 (Inositol Polyphosphate Phosphatase-Like 1 (INPPL1))

Autre désignation: SHIP-2

Sujet: SHIP,INPPL,INPPL1,OPSMD,SHIP2,5 trisphosphate 5 phosphatase 2,51C protein,5-trisphosphate 5-phosphatase 2,EC 3.1.3.n1,inositol polyphosphate phosphatase like 1,Inositol polyphosphate phosphatase like protein 1,Inositol polyphosphate phosphatase-like protein 1,INPPL-1,Phosphatidylinositol 3,Protein 51C,SH2 domain containing inositol 5' phosphatase 2,SH2 domain-containing inositol 5''-phosphatase 2,SH2 domain-containing inositol phosphatase 2,SHIP-2,SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus. Upon receptor cross-linking, SHIP is first recruited to the membrane junction through binding of its SH2 domain to the phospho-tyrosine in the ITIM motif, followed by tyrosine phosphorylation on the NPXY motif. The membrane relocalization and phosphorylation on the NPXY motif is essential for the regulatory function of SHIP1. Its effect on calcium flux, cell survival, growth, cell cycle arrest, and apoptosis is mediated through the PI3K and Akt pathways. Tyr1021 is located in one of the NPXY motifs in SHIP1, and its phosphorylation is important for SHIP1 function.SHIP2, a homolog of SHIP1, is highly expressed in heart, skeletal muscle and placenta.SHIP2 negatively regulates insulin signaling and polymorphisms in SHIP2 have been linked to hyperglycemia. Recent studies also suggest SHIP2 as a therapeutic target for the treatment of both obesity and type 2 diabetes. Tyr1135 is phosphorylated in human cancer cells. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 139 kDa

Observed MW: 140 kDa The actual band is not consistent with the expectation.

UniProt: O15357

Pathways: Platelet-derived growth Factor Receptor Signaling