Recombinant JMJD2D anticorps

N° du produit ABIN7828364

L’anticorps anti-JMJD2D Monoclonal Lapin est utilisé pour la détection de JMJD2D dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Recombinant JMJD2D anticorps (ABIN7828364)

Antigène: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp JMJD2D est non-conjugé

Application: Western Blotting (WB)

Clone: A738

Détail du produit anti-JMJD2D anticorps

Fonction: Recombinant JMJD2D Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur JMJD2D

Antigène: JMJD2D (KDM4D) (Lysine (K)-Specific Demethylase 4D (KDM4D))

Autre désignation: JMJD2D

Sujet: JHD3D,JmjC domain-containing histone demethylation protein 3D,Jumonji domain-containing protein 2D,Lysine-specific demethylase 4D,JHDM3D,JMJD2D,KDM4D,JMJD2D (KDM4D) is a histone demethylase located in the nucleus that specifically demethylates Lysine 9 of Histone H3, thereby playing a central role in the histone code. JMJD2D (KDM4D) demethylates both di- and trimethylated histone H3 Lys 9, while it has no activity on monomethylated residues. The demethylation reaction of the Lys residue generates formaldehyde and succinate as a by product. In addition, JMJD2D forms a complex with the ligand-bound form of the Androgen Receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D (KDM4D) may be involved in carcinogenesis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 59 kDa

Observed MW: 65 kDa The actual band is not consistent with the expectation.

UniProt: Q6B0I6

Pathways: L'effet Warburg