Recombinant MPHOSPH8 anticorps

N° du produit ABIN7828368

Cet anticorps anti-MPHOSPH8 Monoclonal Lapin (Clone A305) (ABIN7828368) détecte spécifiquement MPHOSPH8 dans WB. L’anticorps est réactif avec des échantillons de Souris.

Aperçu rapide pour Recombinant MPHOSPH8 anticorps (ABIN7828368)

Antigène: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Type d'anticorp: Recombinant Antibody

Reactivité: Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MPHOSPH8 est non-conjugé

Application: Western Blotting (WB)

Clone: A305

Détail du produit anti-MPHOSPH8 anticorps

Fonction: Recombinant MPP8 Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human MPP8 fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:500-1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur MPHOSPH8

Antigène: MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))

Autre désignation: MPP8

Sujet: MPP,Mphosph,MPP8,MPHOSPH8,Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites, these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 110 kDa

Observed MW: 125 kDa The actual band is not consistent with the expectation.

UniProt: Q99549