Recombinant MYCN anticorps

N° du produit ABIN7828415

L’anticorps anti-MYCN Monoclonal Lapin est utilisé pour la détection de MYCN dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Recombinant MYCN anticorps (ABIN7828415)

Antigène: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MYCN est non-conjugé

Application: Western Blotting (WB)

Clone: A754

Détail du produit anti-MYCN anticorps

Fonction: Recombinant N-Myc Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:50000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur MYCN

Antigène: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Autre désignation: N-Myc

Sujet: BHLHe,MODED,N-myc,NMYC,ODED,bHLHe37,MYCN,Class E basic helix-loop-helix protein 37,N myc,N myc proto oncogene protein,Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene,Neuroblastoma MYC oncogene,NMYC proto oncogene protein,N-myc proto-oncogene protein,Oncogene NMYC,pp65/67,V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog,v myc avian myelocytomatosis viral related oncogene neuroblastoma derived,v myc myelocytomatosis viral related oncogene neuroblastoma derived,Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior, including proliferation, differentiation, and apoptosis. These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription. Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families. The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior. The Mad family consists of four related proteins, Mad1, Mad2 (Mxi1), Mad3, and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes, such as proliferation, transformation, and prevention of apoptosis by inhibiting transcription.In humans the Myc family consists of 5 genes: c-Myc, N Myc, L-Myc, R-Myc, and B-Myc. While c-Myc is expressed in many proliferating cells, N-Myc expression is very restricted, with highest levels in during embryonic development and then in the adult during B-cell development. These expression patterns and results from targeted deletion of N-Myc suggest that N-Myc plays an important role in tissue development and differentiation. In addition, amplification or overexpression of N-Myc has been found in human neuroblastomas and is associated with rapid progression and poor prognosis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 50 kDa

Observed MW: 62 kDa The actual band is not consistent with the expectation.

UniProt: P04198