Recombinant SMC1A anticorps

N° du produit ABIN7828589

L’anticorps anti-SMC1A Monoclonal Lapin est utilisé pour la détection de SMC1A dans des échantillons de Humain et Souris. Il a été validé pour WB.

Aperçu rapide pour Recombinant SMC1A anticorps (ABIN7828589)

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SMC1A est non-conjugé

Application: Western Blotting (WB)

Clone: A706

Détail du produit anti-SMC1A anticorps

Fonction: Recombinant SMC1A Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000-1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur SMC1A

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Autre désignation: SMC1A

Sujet: SMC,CDLS,KIAA,SMC1L,SMC1A,CDLS2,DXS423E,SB1.8,SMC1,SMC1L1,SMC1alpha,SMCB,KIAA0178,Chromosome segregation protein SmcB,MGC138332,Segregation of mitotic chromosomes 1,SMC protein 1A,SMC1 (structural maintenance of chromosomes 1 yeast) like 1,SMC1 structural maintenance of chromosomes 1 like 1,SMC-1A,SMC-1-alpha,Structural maintenance of chromosomes 1A,Structural maintenance of chromosomes protein 1A,he cohesin complex consists of a heterodimer between SMC1 (SMC1A or B) and SMC3, bound by additional RAD21 and STAG proteins (STAG1, 2, or 3). These proteins form a ring-like structure that mediates the cohesion of two sister chromatids after DNA replication in S phase. RAD21 and STAG2 are phosphorylated by Polo-like kinase (PLK) during prophase, which leads to the dissociation of cohesin complexes from the chromosome arms, however, cohesin remains bound to centromeres until anaphase. RAD21 is cleaved by separin/ESPL1 in anaphase, which leads to dissociation of the remaining cohesin from centromeres, enabling sister chromatids to segregate during mitosis. RAD21 is also cleaved by caspase-3 and caspase-7 during apoptosis, resulting in a 64 kDa carboxy-terminal cleavage product that translocates to the cytoplasm and may help to trigger apoptosis. In addition to mediating cohesion of sister chromatids, the cohesin complex plays important roles in gene regulation and DNA repair, as SMC1 and SMC3 are both phosphorylated by ATM and ATR kinases upon DNA damage. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 141 kDa

Observed MW: 160 kDa The actual band is not consistent with the expectation.

UniProt: Q14683

Pathways: Stem Cell Maintenance