Recombinant TSC1 anticorps

N° du produit ABIN7828644

Cet anticorps anti-TSC1 Monoclonal Lapin (Clone A773) (ABIN7828644) détecte spécifiquement TSC1 dans WB. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour Recombinant TSC1 anticorps (ABIN7828644)

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Type d'anticorp: Recombinant Antibody

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TSC1 est non-conjugé

Application: Western Blotting (WB)

Clone: A773

Détail du produit anti-TSC1 anticorps

Fonction: Recombinant Hamartin Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur TSC1

Antigène: TSC1 (Tuberous Sclerosis 1 (TSC1))

Autre désignation: Hamartin

Sujet: KIAA,TSC1,LAM,TSC,hamartin,KIAA0243,Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that causes symptoms including hamartomas in brain, kidney, heart, lung and skin. The tumor suppressor genes TSC1 and TSC2 encode hamartin and tuberin, respectively. Hamartin and tuberin form a functional complex and are involved in numerous cellular activities such as vesicular trafficking, regulation of the G1 phase of the cell cycle, steroid hormone regulation, Rho activation and anchoring neuronal intermediate filaments to the actin cytoskeleton. The combination of genetic, biochemical and cell-biological studies demonstrate that the tuberin/hamartin complex functions as a GTPase-activating protein for the Ras-related small G protein Rheb and thus inhibits targets of rapamycin including mTOR. Cells lacking hamartin or tuberin fail to inhibit phosphorylation of S6 kinase resulting in the activation of S6 ribosomal protein's translation of 5'TOP mRNA transcripts. Hamartin is phosphorylated by CDK1 (cdc2) at Thr417, Ser584 and Thr1047 in cells in G2/M phase of the cell cycle. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 130 kDa

Observed MW: 160 kDa The actual band is not consistent with the expectation.

UniProt: Q92574

Pathways: Signalisation RTK, AMPK Signaling, Regulation of Cell Size, Tube Formation