Recombinant YAP1 anticorps (pSer127)

N° du produit ABIN7828681

Cet anticorps Lapin Monoclonal détecte spécifiquement YAP1 dans WB, IHC, IF et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant YAP1 anticorps (pSer127) (ABIN7828681)

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp YAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: A804

Détail du produit anti-YAP1 anticorps

Épitope: pSer127

Fonction: Recombinant Phospho-YAP1 (Ser127) Monoclonal Antibody

Purification: Protein A purified

Immunogène: phosphorylated human YAP1 (Ser1270) peptide

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:500-1:2000,IHC 1:100-1:200,IF 1:50,FCM 1:50-1:100

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur YAP1

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Autre désignation: YAP1

Sujet: COB,COB1,YAP,YAP2,YAP65,YKI,YAP1,65 kDa Yes associated protein,65 kDa Yes-associated protein,Basic protease inhibitor,BPTI,Pancreatic Trypsin Inhibitor,Trasylol,YAp 1,YAP 65,Yes associated protein 1,Yes associated protein 1 65 kDa,Yes associated protein 2,yes associated protein beta,yes -associated protein delta,Yorkie homolog,Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 54 kDa

Observed MW: 70-100 kDa The actual band is not consistent with the expectation.

UniProt: P46937

Pathways: Signalisation MAPK, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha