Caldesmon anticorps (C-Term)

N° du produit ABIN7849506

Cet anticorps Lapin Monoclonal détecte spécifiquement Caldesmon dans WB, IHC, IF, FACS, IHC (p) et ICC. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Caldesmon anticorps (C-Term) (ABIN7849506)

Antigène: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Caldesmon est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Détail du produit anti-Caldesmon anticorps

Épitope: C-Term

Fonction: Monoclonal Anti- Caldesmon antibody

Purification: Protein A affinity purified

Immunogène: Asynthetic peptide within C-terminal human Caldesmon.

Isotype: IgG

Information d'application

Indications d'application: Western Blot, WB(1:500-1:1, 000), Immunohistochemistry, IHC-P (1:20-1:100), Immunocytochemistry, ICC/IF (1:20-1:100), Flow Cytometry, Flow-Cyt (1:20-1:50),

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 1*PBS ( pH 7.4), 0.2 % BSA, 40 % Glycerol and 0.05 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Date de péremption: 12 months

Détails sur Caldesmon

Antigène: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Autre désignation: Caldesmon

Sujet: Caldesmon is a protein that in humans is encoded by the CALD1 gene.Caldesmon (CDM) is a potential actomyosin regulatory protein found in smooth muscle and nonmuscle cells. Domain mapping and physical studies suggest that CDM is an elongated molecule with an N-terminal myosin/calmodulin-binding domain and a C-terminal tropomyosin/actin/calmodulin-binding domain separated by a 40-nm-long central helix.1The high molecular weight caldesmon (h-CaD) is predominantly expressed in smooth muscles, whereas the low molecular weight caldesmon (l-CaD) is widely distributed in nonmuscle tissues and cells.2The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction.

Pathways: Myometrial Relaxation and Contraction