Recombinant APC anticorps (C-Term)

N° du produit ABIN7865339

Cet anticorps anti-APC Monoclonal Souris (Clone rEMM43) (ABIN7865339) détecte spécifiquement APC dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant APC anticorps (C-Term) (ABIN7865339)

Antigène: APC (Adenomatous Polyposis Coli (APC))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APC est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: REMM43

Détail du produit anti-APC anticorps

Épitope: C-Term

Expression System: CHO Cells

Fonction: Recombinant APC / Adenomatous Polyposis Coli / FAP (Tumor Suppressor) Antibody

Specificité: The human adenomatous polyposis coli (APC) gene at locus 5q21 encodes a protein of 2,843 amino acids. The precise function of this 300 kD protein is not clear but it may have several functions including a role in cell proliferation, apoptosis, expression of cell adhesion proteins and modulation of cell to cell interactions. It is reported to be expressed in the cytoplasm of cell types of many lineages, both epithelial and mesenchymal. In the epithelium of bladder, small and large intestine, esophagus, stomach and epidermis, APC expression is restricted to regions in which cell replication has ceased and terminal differentiation has been established. Expression has been observed in lung, liver, kidney and mammary gland endothelial, myoepithelial and duct lining epithelial cells. Some tissues such as ovary, myometrium, thyroid, parathyroid and tonsil do not express the protein.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogène: Prokaryotic recombinant protein corresponding to a 251 amino acid region of the C-terminus of the human adenomatous polyposis coli protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur APC

Antigène: APC (Adenomatous Polyposis Coli (APC))

Autre désignation: APC

Sujet:

Adenomatous Polyposis Coli, CC1, Deleted in polyposis 2.5 (DP2.5), DP2, DP3, FAP, FPC, GS, Protein APC

Human tonsil, placenta, breast or colon. HCT116 or COLO 320DM cells.

Poids moléculaire: 66kDa

ID gène: 324, 158932

UniProt: P25054

Pathways: Signalisation WNT, Stem Cell Maintenance, Cell-Cell Junction Organization