Recombinant Choline Acetyltransferase anticorps (C-Term)

N° du produit ABIN7857682

Cet anticorps anti-Choline Acetyltransferase Monoclonal Souris (Clone r38B12) (ABIN7857682) détecte spécifiquement Choline Acetyltransferase dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant Choline Acetyltransferase anticorps (C-Term) (ABIN7857682)

Antigène: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Choline Acetyltransferase est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: R38B12

Détail du produit anti-Choline Acetyltransferase anticorps

Épitope: C-Term

Expression System: CHO Cells

Fonction: Recombinant Choline Acetyltransferase (CHAT) (Marker of Cholinergic Cells) Antibody

Specificité: Choline acetyltransferase (ChAT) is a 68 kD enzyme which catalyses the synthesis of acetylcholine (Ach) from choline and acetyl coenzyme A. The human ChAT gene encodes two proteins, the 68 kD ChAT enzyme and a 27 kD protein immunologically related and coexpressed with ChAT in cholinergic neurons of the central nervous system. The smaller proteins may play a role in the regulation of ACh synthesis. ChAT is expressed in cholinergic neurons, the majority of the neurons in the nucleus basalis of Meynert, large neurones in the striatum (putamen and caudate nuclei), the majority of neurones in the pedunculo-pontine, hypoglossal, dorsal nucleus of vagus and subgroups of neurones in Roller,Ä111s and the medial olivary accessory nuclei. Prominent staining is observed in ribonucleoprotein, distributed at the periphery of large neurons of the nucleus basalis of Meynert, the motor neurons in the hypoglossal and ambiguus nuclei. NCL-ChAT does not label axons in the insular cortex of the internal capsule non-cholinergic structures, endothelial cells or microglia.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogène: Prokaryotic recombinant protein corresponding to the C-terminal region of the human ChAT molecule.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur Choline Acetyltransferase

Antigène: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Autre désignation: Choline Acetyltransferase

Sujet:

CMS1A | CMS1A2 CMS6

Human appendix, colon, stomach or brain.

Poids moléculaire: 82kDa

ID gène: 1103, 410969

UniProt: P28329

Pathways: Skeletal Muscle Fiber Development