Recombinant TARDBP anticorps (C-Term)

N° du produit ABIN7864454

L’anticorps anti-TARDBP Monoclonal Lapin est utilisé pour la détection de TARDBP dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour Recombinant TARDBP anticorps (C-Term) (ABIN7864454)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: TARDP-9299R

Détail du produit anti-TARDBP anticorps

Épitope: C-Term

Expression System: CHO Cells

Fonction: Recombinant TARDBP TAR DNA binding protein / TDP43 Antibody

Specificité: TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

Purification: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogène: Recombinant fragment within human TDP43 aa 200 to the C-terminus.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TARDBP TAR DNA binding protein

Sujet:

TARDBP, TAR DNA binding protein 43 antibody, ALS10

Human cerebrum or colon. Skin

Poids moléculaire: 44kDa

ID gène: 23435, 231829

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion