Recombinant Progesterone Receptor anticorps (AA 1-200)

N° du produit ABIN7863236

L’anticorps anti-Progesterone Receptor Monoclonal Lapin est utilisé pour la détection de Progesterone Receptor dans des échantillons de Humain et Cheval. Il a été validé pour IHC.

Aperçu rapide pour Recombinant Progesterone Receptor anticorps (AA 1-200) (ABIN7863236)

Antigène: Progesterone Receptor (PGR)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Cheval

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Progesterone Receptor est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: PGR-6854R

Détail du produit anti-Progesterone Receptor anticorps

Épitope: AA 1-200

Expression System: HEK-293 Cells

Fonction: Recombinant Progesterone Receptor (Marker of Progestin Dependence) Antibody

Specificité: Progesterone is one of the central regulators of female reproduction. In breast development, progesterone is involved in the formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis. The cellular effects of progesterone are mediated through progesterone receptors (PR). PR, a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor super family of nuclear receptors. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary but is also found in other tissues such as endocrine cells of the Langerhans' islets. The estrogen receptor (ER) and PR status has been used for over 20 years as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

Purification: 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.

Immunogène: Recombinant fragment (around aa 1-200) of human PGR (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Progesterone Receptor

Antigène: Progesterone Receptor (PGR)

Autre désignation: Progesterone Receptor

Sujet:

NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, Progesterone receptor form A, Progesterone receptor form B

Human breast carcinoma.

Poids moléculaire: PR-A (81kDa) and PR-B (116kDa).

ID gène: 5241, 2905

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration