Recombinant MSH6 anticorps (AA 374-540)

N° du produit ABIN7862920

Cet anticorps anti-MSH6 Monoclonal Souris (Clone rMSH6-4743) (ABIN7862920) détecte spécifiquement MSH6 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant MSH6 anticorps (AA 374-540) (ABIN7862920)

Antigène: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MSH6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: RMSH6-4743

Détail du produit anti-MSH6 anticorps

Épitope: AA 374-540

Expression System: HEK-293 Cells

Fonction: Recombinant MSH6 (DNA Mismatch Repair Protein) Antibody

Specificité: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.

Purification: 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.

Immunogène: Recombinant fragment of human MSH6 protein (around aa 374-540) (exact sequence is proprietary)

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur MSH6

Antigène: MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Autre désignation: MSH6

Sujet:

DNA mismatch repair protein Msh6, G/T mismatch-binding protein, GTBP, GTMBP, hMSH6, HNPCC5, HSAP, MSH6, mutS (E. coli) homolog 6, MutS alpha 160 kDa subunit, MutS-alpha 160 kDa subunit, p160, Sperm associated protein

DU 145, HCT116 or HeLa cell lysate (WB). Human colon carcinoma (IHC). HEK293, K-562.

Poids moléculaire: 163kDa

ID gène: 2956, 445052

UniProt: P52701

Pathways: Réparation de l'ADN, Chromatin Binding, Production of Molecular Mediator of Immune Response