Recombinant p40 (p63 Delta) (AA 1-100) anticorps

N° du produit ABIN7863562

Cet anticorps anti-p40 (p63 Delta) Monoclonal Lapin (Clone P40-4396R) (ABIN7863562) détecte spécifiquement p40 (p63 Delta) dans IHC, FACS et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant p40 (p63 Delta) (AA 1-100) anticorps (ABIN7863562)

Antigène: p40 (p63 Delta)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA

Clone: P40-4396R

Détail du produit

Épitope: AA 1-100

Fonction: Recombinant p40 (Squamous, Basal & Myoepithelial Cell Marker) Antibody

Specificité: P40 antibody (antibody recognizing Np63 only) is an isoform of p63, is thought to function as a stem cell factor, responsible for maintaining cells in an uncommitted state with regenerative potential a role that may be recapitulated in tumors derived from these cells. p40 is normally expressed in the basal or progenitor cell layer of stratified epithelia (eg. squamous, urothelial, bronchial), basal cells of some glandular epithelia (eg. prostate), as well as myoepithelial cells of breast and salivary glands, trophoblasts and thymic epithelial cells. In tumor tissues, p40 expression is specific for squamous cell carcinoma. p40 is equivalent to p63 in sensitivity for lung squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. p40 appears to be a more reliable marker for squamous cell carcinoma.

Purification: 200ug/ml of Ab purified by Protein A Column.

Immunogène: Recombinant fragment (around aa1-100) of human p40 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détail du antigène

Antigène: p40 (p63 Delta)

Autre désignation: p40

Sujet:

Amplified in squamous cell carcinoma (AIS), Chronic ulcerative stomatitis protein (CUSP), EEC3, TP73L, LMS, TP63, Keratinocyte transcription factor KET, NBP, P51/P63, p53 like transcription factor, RHS, SHFM4, TAp63alpha, TP53CP, TP53L, Transformation-related protein 63, Trp53rp1, Trp6,3, Tumor protein p53-like, tumor protein p73-like

HEK293, lung or bladder squamous cell carcinoma tissue., MDA-MB453 or MCF7 cells. Human prostate

Poids moléculaire: 63kDa

ID gène: 8626, 137569

UniProt: Q9H3D4