Recombinant p40 (p63 Delta) (AA 5-17) anticorps

N° du produit ABIN7863560

Cet anticorps anti-p40 (p63 Delta) Monoclonal Lapin (Clone ZR8) (ABIN7863560) détecte spécifiquement p40 (p63 Delta) dans IHC, FACS et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant p40 (p63 Delta) (AA 5-17) anticorps (ABIN7863560)

Antigène: p40 (p63 Delta)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: ZR8

Détail du produit

Épitope: AA 5-17

Fonction: Recombinant p40 (deltaNp63) (Squamous, Basal & Myoepithelial Cell Marker) Antibody

Specificité: P63 consists of two major isoforms-TAp63 and delta-Np63. These isoforms differ in the structure of the N-terminal domains. The TAp63 isoform (identified by anti-p63 antibody) contains a transactivation-competent TA domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, DNp63 isoform (identified by anti-p40 antibody) contains an alternative transcriptionally-inactive delta-N domain, which antagonizes the activity of TAp63 and p53. The p40 (clone ZR8) antibody recognizes exclusively delta-Np63 but not TAp63. p40 is a squamous cell carcinoma specific antibody. It reacts with the vast majority of cases of squamous cell carcinomas of various origins, but not with adenocarcinomas. It is particularly useful in differentiating lung squamous cell carcinoma from lung poorly differentiated adenocarcinoma. p40 antibody can also be used as an alternative basal cell/myoepithelial cell marker, which has similar sensitivity and specificity as that of p63 antibody. Therefore, p40 antibody may also be used as an alternative immunohistochemical marker for determining prostate adenocarcinoma vs. benign prostate glands and for determining breast intraductal carcinoma vs. invasive breast ductal carcinoma.

Purification: 200ug/ml of Ab purified by Protein A Column.

Immunogène: Synthetic peptide (ENNAQTQFSEPQY) corresponding to aa5-17 of human p63 protein

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détail du antigène

Antigène: p40 (p63 Delta)

Autre désignation: p40

Sujet:

deltaNp63, TP63

HeLa cells. Human prostate or lung tissue (IHC).

Poids moléculaire: 40kDa

ID gène: 8626, 137569

UniProt: Q9H3D4