Recombinant CD59 anticorps

N° du produit ABIN7863665

L’anticorps anti-CD59 Monoclonal Lapin est utilisé pour la détection de CD59 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Recombinant CD59 anticorps (ABIN7863665)

Antigène: CD59

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD59 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: MACIF-7021R

Détail du produit anti-CD59 anticorps

Fonction: Recombinant CD59 / Complement Regulatory Protein / Protectin Antibody

Specificité: Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein (Workshop VI, Code N-L036). CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb recognizes CD59 transfected cells. It is useful for study on GPI-anchored proteins, PNH and CD59 functions.

Purification: 200ug/ml of Ab purified by Protein A.

Immunogène: Recombinant human full-length CD59 protein

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CD59

Antigène: CD59

Autre désignation: CD59

Sujet:

20 kDa homologous restriction factor (HRF20), Complement regulatory protein, Human leukocyte antigen MIC11, MAC-inhibitory protein (MACIP), Membrane attack complex inhibition factor (MACIF), Membrane inhibitor of reactive lysis, MIRL, MSK21, Protectin, T cell activating protein

Daudi, Jurkat or Raji cells. Human lymphocytes. Human lymph node or tonsil., K562

Poids moléculaire: 20kDa

ID gène: 966, 278573, 709466

UniProt: P13987

Pathways: Système du Complément