Recombinant Estrogen Receptor alpha anticorps (C-Term)

N° du produit ABIN7862759

L’anticorps anti-Estrogen Receptor alpha Monoclonal Lapin est utilisé pour la détection de Estrogen Receptor alpha dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Recombinant Estrogen Receptor alpha anticorps (C-Term) (ABIN7862759)

Antigène: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Estrogen Receptor alpha est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: ESR1-4039R

Détail du produit anti-Estrogen Receptor alpha anticorps

Épitope: C-Term

Fonction: Recombinant Estrogen Receptor, alpha (Marker of Estrogen Dependence) Antibody

Specificité: Recognizes a protein of 67 kDa, which is identified as estrogen receptor (ER) alpha. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to antiestrogen (e.g. tamoxifen) therapy.

Purification: 200ug/ml of Ab purified by Protein A/G.

Immunogène: Recombinant fragment corresponding to C-terminus of human ER-α

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Estrogen Receptor alpha

Antigène: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Autre désignation: Estrogen Receptor, alpha

Sujet:

Estrogen Receptor alpha delta 4*5,6,7*/654 isoform,Estrogen Receptor alpha delta 4 +49 isoform, Nuclear receptor subfamily 3 group A member 1

Humanbreast or endometrial carcinoma.

Poids moléculaire: ~67kDa

ID gène: 2099, 208124

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly