Recombinant E2F4 anticorps (AA 1-100)

N° du produit ABIN7864679

Cet anticorps Lapin Monoclonal détecte spécifiquement E2F4 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant E2F4 anticorps (AA 1-100) (ABIN7864679)

Antigène: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp E2F4 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: E2F4-8811R

Détail du produit anti-E2F4 anticorps

Épitope: AA 1-100

Fonction: Recombinant E2F4 (Transcription Factor) Antibody

Specificité: The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 is a member of a broader family of transcription regulators including E2F-2, E2F-3, E2F-4, E2F-5, E2F-6 and E2F-7 each of which forms heterodimers with a second protein, DP-1, forming an active E2F transcriptional regulatory complex.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-100) of human E2F4 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur E2F4

Antigène: E2F4 (E2F Transcription Factor 4, P107/p130-Binding (E2F4))

Autre désignation: E2F4

Sujet:

E2F transcription factor 4, E2F transcription factor 4 p107/p130 binding, E2F-4, p107/p130 binding protein

Brain|Found in all tissue examined including heart|kidney and pancreas.|liver|lung|Placenta|skeletal muscle

Poids moléculaire: 60kDa

ID gène: 1874, 108371

UniProt: Q16254

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size