IL-18 anticorps (AA 1-193)

N° du produit ABIN7864945

Cet anticorps anti-IL-18 Monoclonal Souris (Clone IL18-4628) (ABIN7864945) détecte spécifiquement IL-18 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour IL-18 anticorps (AA 1-193) (ABIN7864945)

Antigène: IL-18 (IL18) (Interleukin 18 (IL18))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-18 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: IL18-4628

Détail du produit anti-IL-18 anticorps

Épitope: AA 1-193

Fonction: IL-18 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody

Specificité: Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1±, IL-1≤ and IL-1≥/IL-18 and a specific receptor antagonist, IL-1R±. IL-1± and IL-1≤ play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1≥) has been shown to augment the secretion of IFN-≥ from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19 % and 12 % identity with IL-1± and IL-1≤ respectively over the 12 ≤-strands of the ≤-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1≤ pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-≥-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-193) of human IL-18 protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur IL-18

Antigène: IL-18 (IL18) (Interleukin 18 (IL18))

Autre désignation: IL-18

Sujet:

Iboctadekin, IFN gamma inducing factor, IGIF, IL1 gamma, IL18, IL18 protein, IL1F4, IL1g, IL1gamma, Interleukin 18, Interleukin-1 gamma, MGC12320

Human heart or adrenal gland. Stimulated peritoneal macrophages.

Poids moléculaire: 18kDa

ID gène: 3606, 83077

UniProt: Q14116

Pathways: Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome