Recombinant PMS2 anticorps (AA 1-200)

N° du produit ABIN7864322

Cet anticorps anti-PMS2 Monoclonal Lapin (Clone PMS2-8374R) (ABIN7864322) détecte spécifiquement PMS2 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant PMS2 anticorps (AA 1-200) (ABIN7864322)

Antigène: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp PMS2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: PMS2-8374R

Détail du produit anti-PMS2 anticorps

Épitope: AA 1-200

Fonction: Recombinant PMS2 (Postmeiotic Segregation Increased 2) Antibody

Specificité: PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15 % of all colon cancers. Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS), also known as Turcot syndrome or brain tumor-polyposis syndrome 1 (BTPS1). MMRCS is an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas. Skin features include sebaceous cysts, hyperpigmented and cafe au lait spots.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-200) of human PMS2 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur PMS2

Antigène: PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))

Autre désignation: PMS2

Sujet:

DNA mismatch repair protein PMS2, hereditary non-polyposis colorectal cancer type 4 (HNPCC4), Mismatch repair gene PMSL2, PMS1 protein homolog 2, postmeiotic segregation increased 2 (S. cerevisiae), PMS2CL

Human colon carcinoma.

Poids moléculaire: 96kDa

ID gène: 5395, 632637

UniProt: P54278

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response