TFAM anticorps (AA 1-200)

N° du produit ABIN7865304

Cet anticorps anti-TFAM Monoclonal Souris (Clone TFAM-9713) (ABIN7865304) détecte spécifiquement TFAM dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TFAM anticorps (AA 1-200) (ABIN7865304)

Antigène: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TFAM est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: TFAM-9713

Détail du produit anti-TFAM anticorps

Épitope: AA 1-200

Fonction: TFAM / TCF6 (Transcription factor A, mitochondrial) / mtTFA Antibody

Specificité: MtTFA (mitochondrial transcription factor A), also known as mtTF1, TFAM, TCF6 (for transcription factor 6-like1), TCF6L2 and tsHMG, is a nuclear-encoded gene product that is imported into the mitochondria. mtTFA is required for many aspects of mitochondrial biogenesis including the replication and transcription of mitochondrial DNA (mtDNA). In mouse, testis-specific mtTFA is missing the mitochondria targeting sequence and is present in the nucleus rather than the mitochondria. This form of mtTFA is located primarily in the nuclei of elongated spermatids and may be involved in the regulation of gene expression of the haploid male genome. During mouse and human spermatogenesis there is a reduction of mtTFA protein levels and a reduction in mtDNA copy number. These features may provide one of the mechanisms by which paternal mtDNA transmission is prevented. mtTFA has been associated with mitochondrial disorder in humans characterized by ocular myopathy, exercise intolerance and muscle wasting.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-200) of human TFAM protein (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur TFAM

Antigène: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Autre désignation: TFAM

Sujet:

TCF6, MTTF1, MTTFA, TCF6L1, TCF6L2, TCF6L3, MTDPS15

HEK293T

Poids moléculaire: 25kDa

ID gène: 7019, 642966

UniProt: Q00059

Pathways: Chromatin Binding