Mannose Receptor anticorps (AA 1100-1400)

N° du produit ABIN7865255

Cet anticorps Souris Monoclonal détecte spécifiquement Mannose Receptor dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Mannose Receptor anticorps (AA 1100-1400) (ABIN7865255)

Antigène: Mannose Receptor (MR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Mannose Receptor est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: MRC1-9456

Détail du produit anti-Mannose Receptor anticorps

Épitope: AA 1100-1400

Fonction: Mannose Receptor / CD206 Antibody

Specificité: CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1100-1400) of human MRC1 protein (exact sequence is proprietary)

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur Mannose Receptor

Antigène: Mannose Receptor (MR)

Autre désignation: Mannose Receptor

Sujet: C-type lectin domain family 13 member D, human mannose receptor, macrophage mannose receptor 1-like protein 1, mannose receptor, C type 1-like 1

Poids moléculaire: 160-170kDa

ID gène: 4360, 75182

UniProt: P22897