ERCC1 anticorps (AA 191-281)

N° du produit ABIN7859358

L’anticorps anti-ERCC1 Monoclonal Souris est utilisé pour la détection de ERCC1 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour ERCC1 anticorps (AA 191-281) (ABIN7859358)

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ERCC1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: ERCC1-7596

Détail du produit anti-ERCC1 anticorps

Épitope: AA 191-281

Fonction: ERCC1 / RAD10 (Tumor Progression Marker) Antibody

Specificité: Recognizes a protein of 110 kDa, identified as Excision Repair Cross Complementing 1 (ERCC1). It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa 191-281) of human ERCC1 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur ERCC1

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Autre désignation: ERCC1

Sujet:

COFS4, DNA excision repair protein ERCC1, ERCC1, Excision repair cross complementing 1, RAD10, UV20

HeLa or HepG2 cells. Tonsil or Prostate.

Poids moléculaire: 110kDa

ID gène: 2067, 435981

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response