IGKV1-27 anticorps (AA 241-356)

N° du produit ABIN7859624

Cet anticorps Souris Monoclonal détecte spécifiquement IGKV1-27 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour IGKV1-27 anticorps (AA 241-356) (ABIN7859624)

Antigène: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGKV1-27 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: TNFAIP3-2813

Détail du produit anti-IGKV1-27 anticorps

Épitope: AA 241-356

Fonction: A20 / TNFAIP3 (Marker of Tamoxifen Resistance) Antibody

Specificité: A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. HighA20expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa 241-356) of human TNFAIP3 protein (exact sequence is proprietary)

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur IGKV1-27

Antigène: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Autre désignation: A20

Sujet:

A20, Putative DNA-binding protein A20, TNF alpha-induced protein 3 (TNFAIP3), Tumor Necrosis Factor alpha-Induced Protein 3(TNFAIP3), Zinc finger protein A20

Hodgkin s Lymphoma or hepatocellular carcinoma (HCC).

Poids moléculaire: ~90kDa

ID gène: 7128, 211600

UniProt: P21580

Pathways: Activation of Innate immune Response