IGKV1-27 anticorps (AA 241-356)

N° du produit ABIN7872742

Cet anticorps anti-IGKV1-27 Monoclonal Souris (Clone TNFAIP3-2813) (ABIN7872742) détecte spécifiquement IGKV1-27 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour IGKV1-27 anticorps (AA 241-356) (ABIN7872742)

Antigène: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGKV1-27 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TNFAIP3-2813

Détail du produit anti-IGKV1-27 anticorps

Épitope: AA 241-356

Fonction: A20 Antibody / TNFAIP3

Purification: Protein G affinity chromatography

Immunogène: A portion of amino acids 241-356 from the human protein was used as the immunogen for the A20 antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal dilution of the A20 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the A20 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur IGKV1-27

Antigène: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Autre désignation: A20

Sujet: A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. High A20 expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.

UniProt: P21580

Pathways: Activation of Innate immune Response