Fascin anticorps (AA 350-400)

N° du produit ABIN7859963

Cet anticorps Souris Monoclonal détecte spécifiquement Fascin dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Fascin anticorps (AA 350-400) (ABIN7859963)

Antigène: Fascin (FSCN1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fascin est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: FSCN1-7209

Détail du produit anti-Fascin anticorps

Épitope: AA 350-400

Fonction: Fascin-1 (Reed-Sternberg Cell Marker) Antibody

Specificité: Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa350-400) of human FSCN1 protein (exact sequence is proprietary)

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Fascin

Antigène: Fascin (FSCN1)

Autre désignation: Fascin-1

Sujet:

55 kDa actin-bundling protein, FAN1, Fascin homolog 1, Fascin1, FSCN1, HSN, p55, Singed (Drosophila) like (sea urchin fascin homolog like), SNL

HeLa, MCF-7, Ovarian or Testicular Carcinoma., PC-3 or BEWO cells. Hodgkin s lymphoma

Poids moléculaire: 55kDa

ID gène: 6624, 118400

UniProt: Q16658