EBI3 anticorps (AA 366-466)

N° du produit ABIN7860030

L’anticorps anti-EBI3 Monoclonal Souris est utilisé pour la détection de EBI3 dans des échantillons de Humain. Il a été validé pour ELISA et IHC.

Aperçu rapide pour EBI3 anticorps (AA 366-466) (ABIN7860030)

Antigène: EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EBI3 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Clone: EBI3-8902

Détail du produit anti-EBI3 anticorps

Épitope: AA 366-466

Fonction: EBI3 / Epstein-Barr virus induced 3 Antibody

Specificité: Epstein-Barr virus-induced gene 3 (Ebi3) is a widely expressed homolog to the interleukin IL-12 p40 subunit protein that forms a heterodimer with either IL-12 p35 or an IL-12 p35 homolog, p28, to create a new cytokine (IL-27). IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4+ T cells. Interferon-b differentially regulates expression of the IL-12 family members p35, p40, p19 and Ebi3 in activated human dendritic cells. Ebi3 may function to antagonize IL-12 and to inhibit the development of a Th1 immune response. Ebi3 is strongly expressed in Hodgkin and Reed-Sternberg cells, independently of the EBV status of the tumor cells. Research suggests that Ebi3 may be an additional component of the repertoire employed by Hodgkin and Reed-Sternberg cells to inhibit an effective anti-tumor or anti-viral immune response. The human Ebi3 gene maps to chromosome 19p13.3 and encodes a secreted glycoprotein that is expressed in spleen and tonsils, and at high levels in full-term placenta.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa 366-466) of human EBI3 protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur EBI3

Antigène: EBI3 (IL-27b) (Interleukin-27 subunit beta (IL-27b))

Autre désignation: EBI3

Sujet:

cytokine receptor, EBI3, EBV induced gene 3 protein, Epstein Barr virus induced 3, Epstein Barr virus induced gene 3, Epstein Barr virus induced gene 3 protein, IL27 subunit beta, IL27B, IL35 subunit, interleukin 27 subunit beta

Human placenta.

Poids moléculaire: 34 kDa

ID gène: 10148, 501452

UniProt: Q14213