SIGLEC10 anticorps (AA 500-697)

N° du produit ABIN7860285

L’anticorps anti-SIGLEC10 Monoclonal Souris est utilisé pour la détection de SIGLEC10 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour SIGLEC10 anticorps (AA 500-697) (ABIN7860285)

Antigène: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIGLEC10 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: SIGLEC10-7582

Détail du produit anti-SIGLEC10 anticorps

Épitope: AA 500-697

Fonction: SIGLEC10 Antibody

Specificité: Siglec-10 (sialic acid-binding Ig-like lectin 10) is a 697 amino acid protein belonging to the immunoglobulin superfamily. The N-terminal Ig-like domain of Siglec-10 contains a sialic acid-binding site and the C-terminal cytoplasmic region of Siglec-10 contains two immunoreceptor tyrosine-based inhibitor motifs (ITIMs), which are involved in the modulation of cellular responses through SH2 domains. With most expression in spleen, bone marrow and peripheral blood lymphocytes, such as monocytes, natural killer cells and eosinophils, it is likely that Siglec-10 functions as an inhibitory receptor in the immune response. Importantly, Siglec-10 mRNA is found to be highly upregulated in eosinophils at sites of inflammation in asthmatics, suggesting that Siglec-10 may be an appropriate target for new approaches of immunomodulatory therapy. There are six named isoforms of Siglec-10 that are a result of alternative splicing. All isoforms exists as single-pass transmembrane proteins, except for isoform 6, which is secreted.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa500-697) of human SIGLEC10 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur SIGLEC10

Antigène: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Autre désignation: SIGLEC10

Sujet:

mSiglec G, PRO940, sialic acid binding Ig like lectin 10 Ig like lectin 7, Sialic acid binding Immunoglobulin like lectin 10, Siglec G, siglec like gene 2, Siglec like protein 2, Siglecg, SLG2

Expressed by peripheral blood leukocytes (eosinophils|lung|monocytes and a natural killer cell subpopulation). Isoform 5 is found in lymph node|ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow|spleen a

Poids moléculaire: 77kDa

ID gène: 89790, 284813

UniProt: Q96LC7