PIK3CD anticorps (AA 520-720)

N° du produit ABIN7865035

L’anticorps anti-PIK3CD Monoclonal Souris est utilisé pour la détection de PIK3CD dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour PIK3CD anticorps (AA 520-720) (ABIN7865035)

Antigène: PIK3CD (Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide (PIK3CD))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PIK3CD est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: PIK3CD-4639

Détail du produit anti-PIK3CD anticorps

Épitope: AA 520-720

Fonction: PIK3CD Antibody

Specificité: Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85a and p85b), each possessing one SH3 and two SH2 domains. Various p110 forms have been identified. p110a and p110b interact with p85a, and p110a has also been shown to interact with p85b in vitro. It has been shown to bind p85a and b, but it apparently does not phosphorylate these subunits. p110d has the capacity to autophosphorylate and results in the nearly complete inactivation of the lipid kinase activity. Interestingly, p110g does not interact with the p85 subunits and has been shown to be activated by a and bg heterotrimeric G proteins. Two p110d isoforms have been identified and are widely expressed. Isoform 1 is expressed predominantly in leukocytes while isoform 2 is expressed in normal thymus, lung and spleen tissues.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human PIK3CD protein (around aa 520-720) (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur PIK3CD

Antigène: PIK3CD (Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide (PIK3CD))

Autre désignation: PIK3CD

Sujet:

5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, APDS, GRB1, IMD14, p110delta, p110dp85a, p85-ALPHA, Phosphoinositide 3 kinase B, Phosphoinositide 3 kinase C, Phosphoinositide 3 kinase catalytic delta polypeptide, Phosphoinositide 3 kinase, catalytic, delta polypeptide variant p37delta, PI3K-delta, PIK3R1, PtdIns 3 kinase p110, PtdIns 3 kinase subunit p110 delta, PtdIns-3-kinase subunit delta, PtdIns-3-kinase subunit p110-delta

lymph node or tonsil|THP1 cells. Human spleen

Poids moléculaire: 119/33kDa

ID gène: 5293, 518451

UniProt: O00329

Pathways: BCR Signaling, L'effet Warburg