TARDBP anticorps (C-Term)

N° du produit ABIN7860723

L’anticorps anti-TARDBP Monoclonal Souris est utilisé pour la détection de TARDBP dans des échantillons de Humain. Il a été validé pour WB, IHC et ELISA.

Aperçu rapide pour TARDBP anticorps (C-Term) (ABIN7860723)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: TARDP-349

Détail du produit anti-TARDBP anticorps

Épitope: C-Term

Fonction: TARDBP TAR DNA binding protein / TDP43 Antibody

Specificité: TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment within human TDP43 aa 200 to the C-terminus.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TARDBP TAR DNA binding protein

Sujet:

TARDBP, TAR DNA binding protein 43 antibody, ALS10

Human cerebrum or colon.

Poids moléculaire: 44kDa

ID gène: 23435, 231829

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion