Cathepsin D anticorps

N° du produit ABIN7862684

Cet anticorps Souris Monoclonal détecte spécifiquement Cathepsin D dans WB et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Cathepsin D anticorps (ABIN7862684)

Antigène: Cathepsin D (CTSD)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cathepsin D est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: CTSD-4497

Détail du produit anti-Cathepsin D anticorps

Fonction: Cathepsin D (Tumor Marker) Antibody

Specificité: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43kDa preprocathepsin D that is cleaved and glycosylated to form a 46kDa procathepsin D and then further cleaved to produce 28kDa and 15kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Purified His-tagged CTSD protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Cathepsin D

Antigène: Cathepsin D (CTSD)

Autre désignation: Cathepsin D

Sujet:

CatD, Cathepsin D, Ceroid lipofuscinosis neuronal 10, CLN10, CPSD, Epididymis secretory sperm binding protein Li 130P, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease

A431 or SK-BR3 cells. Kidney, Liver, lung or breast., MCF-7

Poids moléculaire: 48kDa (Procathepsin D), 43kDa (preprocathepsin D), 34kDa (Cathepsin D), 28kDa (heavy chain), 15kDa (light chain)

ID gène: 1509, 654447

UniProt: P07339

Pathways: Peptide Hormone Metabolism