HES5 anticorps

N° du produit ABIN7865264

Cet anticorps Souris Monoclonal détecte spécifiquement HES5 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour HES5 anticorps (ABIN7865264)

Antigène: HES5 (Hairy and Enhancer of Split 5 (HES5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HES5 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: HES5-8035

Détail du produit anti-HES5 anticorps

Fonction: HES5 / bHLHb38 / Hes family bHLH transcription factor 5 Antibody

Specificité: The Drosophila Hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila Hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human HES5 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur HES5

Antigène: HES5 (Hairy and Enhancer of Split 5 (HES5))

Autre désignation: HES5

Sujet: BHLHb38

Poids moléculaire: 41kDa

ID gène: 388585, 57971

UniProt: Q5TA89

Pathways: Stem Cell Maintenance, Tube Formation