MIF anticorps

N° du produit ABIN7861669

Cet anticorps anti-MIF Monoclonal Souris (Clone MIF-6278) (ABIN7861669) détecte spécifiquement MIF dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour MIF anticorps (ABIN7861669)

Antigène: MIF (Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) (MIF))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MIF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: MIF-6278

Détail du produit anti-MIF anticorps

Fonction: MIF (Macrophage Migration Inhibitory Factor) Antibody

Specificité: Macrophage migration inhibitory factor, known as MIF or glycosylationinhibiting factor, is a secreted, homotrimeric, pro-inflammatory cytokine that modulates macrophage and T cell function and is an important regulator of host response to infection. MIF is expressed at sites of inflammation, which suggests that it plays a role in regulating macrophage function in host defense. MIF is produced by the pituitary gland and is found in monocytes, macrophages, differentiating immunological cells in the eye lens and brain, and fibroblasts. Elevated levels of MIF protein are detected in the plasma of patients with severe sepsis or septic shock, a condition where MIF influences endotoxic shock by enhancing the production of other inflammatory cytokines including tumor necrosis factor é 79oΩ (TNFé 79oΩ), interleukin-1 (IL-1) and interferon-é 79oΩ (IFN-é 79oΩ). MIF promotes the systemic inflammatory response by counter-regulating glucocorticoid-mediated inhibition of immune-cell activation and proinflammatory cytokine production. MIF may mediate tissue destruction through the induction of proteinases.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human MIF protein (exact sequence is proprietary)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur MIF

Antigène: MIF (Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) (MIF))

Autre désignation: MIF

Sujet:

GIF, GLIF, Glycosylation inhibiting factor, L-dopachrome isomerase, L-dopachrome tautomerase, Macrophage migration inhibitory factor (glycosylation-inhibiting factor), MIF, MIF protein, MMIF, Phenylpyruvate tautomerase

Human tonsil, thymus or prostate. PC3 or HEK-293 cells.

Poids moléculaire: 13kDa

ID gène: 4282, 407995

UniProt: P14174

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling