PRMT6 anticorps

N° du produit ABIN7863271

Cet anticorps Souris Monoclonal détecte spécifiquement PRMT6 dans IF et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PRMT6 anticorps (ABIN7863271)

Antigène: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRMT6 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-PRMT6-2C9

Détail du produit anti-PRMT6 anticorps

Fonction: PRMT6 Antibody

Specificité: A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMTs contain an S-adenosylmethione motif which functions to add one or two methyl groups to guanidino nitrogens of arginine (R) side chains. PRMT6, also known as HRMT1L6, is a nuclear protein belonging to the PRMT family and is predominantly expressed in testis and kidney. It is known to methylate Histones H3, H4 and H2A. PRMT6 is the major dimethyltransferase for Histone H3 and specifically methylates Histone H3 at R2. Methylation at Histone H3 R2 acts to inhibit Histone H3 K4 trimethylation and ultimately leads to the transcriptional repression of genes that are activated by Histone H3 K4 trimethylation. In addition, PRMT6 methylates HIV TAT, possibly functioning as a form of cellular innate immunity to restrict levels of HIV replication.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human PRMT6 protein

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur PRMT6

Antigène: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Autre désignation: PRMT6

Sujet:

Chromobox protein homolog 7, Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6, Histone-arginine N-methyltransferase PRMT6, HMT1 hnRNP methyltransferase like 6., HRMT1L6

HeLa, MCF7 or HepG2 cells.

Poids moléculaire: 42kDa

ID gène: 55170, 26006

UniProt: Q96LA8