SATB1 anticorps

N° du produit ABIN7862050

Cet anticorps anti-SATB1 Monoclonal Souris (Clone SATB1-2661) (ABIN7862050) détecte spécifiquement SATB1 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SATB1 anticorps (ABIN7862050)

Antigène: SATB1 (SATB Homeobox 1 (SATB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SATB1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: SATB1-2661

Détail du produit anti-SATB1 anticorps

Fonction: SATB1 (Marker of Lymph Node Metastasis of CRC) Antibody

Specificité: The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus. The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human SATB1 protein

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur SATB1

Antigène: SATB1 (SATB Homeobox 1 (SATB1))

Autre désignation: SATB1

Sujet:

DNA-binding protein SATB1, SATB family member 1, SATB homeobox 1, SATB1, Special AT-rich sequence-binding protein 1

Fetal thymus or tonsil (IHC).

Poids moléculaire: 115kDa

ID gène: 6304, 517717

UniProt: Q01826

Pathways: Caspase Cascade in Apoptosis, Activated T Cell Proliferation