TMPRSS2 anticorps

N° du produit ABIN7862215

Cet anticorps anti-TMPRSS2 Monoclonal Souris (Clone TMPRSS2-7410) (ABIN7862215) détecte spécifiquement TMPRSS2 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TMPRSS2 anticorps (ABIN7862215)

Antigène: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TMPRSS2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: TMPRSS2-7410

Détail du produit anti-TMPRSS2 anticorps

Fonction: TMPRSS2 (Transmembrane Serine Protease 2) Antibody

Specificité: Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland. TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain. TMPRSS2 is expressed as a full length form and a cleaved protease domain and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant full-length human TMPRSS2 protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur TMPRSS2

Antigène: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Autre désignation: TMPRSS2

Sujet:

D16Ertd61e, Epitheliasin, FLJ41954, MGC6821, PP9284, PRSS10, Serine protease 10, TMPRSS2 ETV1 FUSION GENE, INCLUDED, Transmembrane protease serine 2 catalytic chain, Transmembrane protease, serine 2, EC 3.4.219

colon|Expressed strongly in small intestine. Also expressed in prostate|stomach and salivary gland.

Poids moléculaire: 70kDa

ID gène: 7113, 439309

UniProt: O15393

Pathways: SARS-CoV-2 Protein Interactome