beta Amyloid anticorps (AA 500-700)

N° du produit ABIN7862386

Cet anticorps anti-beta Amyloid Monoclonal Souris (Clone APP-3667) (ABIN7862386) détecte spécifiquement beta Amyloid dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour beta Amyloid anticorps (AA 500-700) (ABIN7862386)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Amyloid est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: APP-3667

Détail du produit anti-beta Amyloid anticorps

Épitope: AA 500-700

Fonction: beta Amyloid Antibody

Specificité: Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the ≤-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid ≤/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

Purification: 200ug/ml of Ab purified from rabbit anti-serum by Protein A.

Immunogène: Recombinant fragment (around aa500-700) of human APP protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: beta Amyloid

Sujet:

CVAP, AAA, AICD-50, PN2, 50, Beta-APP42, AID, S-APP-alpha, 57, AD1, PN-II, Beta-APP40, 42, 40, APPI, Alzheimer disease amyloid protein, PreA4, ABETA, Amyloid intracellular domain 50, 57, 59 AICD-59, S-APP-beta, APP, AICD-57, ABPP, Protease nexin-II, Cerebral vascular amyloid peptide

Alzheimer's diseased brain. Amyloidosis.

Poids moléculaire: 4-46kDa (≤-Amyloid), 100-125kDa (Amyloid A4)

ID gène: 351, 434980

UniProt: P05067

Pathways: Inflammasome