MSH2 anticorps

N° du produit ABIN7865693

Cet anticorps Souris Monoclonal détecte spécifiquement MSH2 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MSH2 anticorps (ABIN7865693)

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MSH2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: IHC410

Détail du produit anti-MSH2 anticorps

Fonction: anti-MSH2 mouse monoclonal, IHC410, purified

Purification: affinity chromatography

Immunogène: Recombinant Human MSH2

Isotype: IgG2b

Information d'application

Indications d'application: Optional[ICC/IF_dilution]: 1:50-1:200 (microwave treatment recommended)

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Tris pH 7.3-7.7 with 1 % BSA and 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: store at 2 - 8 °C

Détails sur MSH2

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Autre désignation: MSH2

Sujet: MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumours that are microsatellite-unstable.

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response