S100A8/A9 Complex (Calprotectin) anticorps (AA 1-100)

N° du produit ABIN7867818

L’anticorps anti-S100A8/A9 Complex (Calprotectin) Monoclonal Souris est utilisé pour la détection de S100A8/A9 Complex (Calprotectin) dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour S100A8/A9 Complex (Calprotectin) anticorps (AA 1-100) (ABIN7867818)

Antigène: S100A8/A9 Complex (Calprotectin) (S100A8/A9) (Calprotectin (S100A8/A9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp S100A8/A9 Complex (Calprotectin) est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: S100A9-7551

Détail du produit anti-S100A8/A9 Complex (Calprotectin) anticorps

Épitope: AA 1-100

Fonction: Calprotectin Antibody / S100A9 / MRP14

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 1-100) from the human protein was used as the immunogen for the Calprotectin antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the Calprotectin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Calprotectin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur S100A8/A9 Complex (Calprotectin)

Antigène: S100A8/A9 Complex (Calprotectin) (S100A8/A9) (Calprotectin (S100A8/A9))

Autre désignation: Calprotectin

Sujet: This mAb stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffer s cells of the liver and Langerhan s cells of the skin. It also stains the mantle zone B-lymphocytes of the lymph node and spleen, spermatogonia, and chief cells of the stomach. S100A9 is expressed by macrophages in acutely inflamed tissues and in chronic inflammation. It is detected in peripheral blood leukocytes, in neutrophils and granulocytes. It is present at sites of vascular inflammation. S100A9 is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a Calcium-binding protein. It has antimicrobial activity towards bacteria and fungi. It is important for resistance to invasion by pathogenic bacteria. It up-regulates transcription of genes that are under the control of NF-kappa-B. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. It plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.

UniProt: P06702

Pathways: S100 Proteins