Recombinant TdT anticorps (AA 1-100)

N° du produit ABIN7867840

Cet anticorps anti-TdT Monoclonal Souris (Clone rDNTT-6909) (ABIN7867840) détecte spécifiquement TdT dans ELISA et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant TdT anticorps (AA 1-100) (ABIN7867840)

Antigène: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TdT est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RDNTT-6909

Détail du produit anti-TdT anticorps

Épitope: AA 1-100

Fonction: DNTT Antibody / TdT / DNA Nucleotidylexotransferase

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 1-100 was used as the immunogen for the DNTT antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the DNTT antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the DNTT antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TdT

Antigène: TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))

Autre désignation: DNTT

Sujet: Terminal deoxynucleotidyl transferase (TdT) is an unusual deoxynucleotide polymerizing enzyme with a molecular weight of about 58 kDa found normally only in B- and T-cell lymphoblasts/prelymphocytes. TdT generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Rare TdT-positive cells are regularly detected in thymus and bone marrow. Typically, TdT expression in the thymus is very variable from cell to cell since it is rapidly decreased in more mature T-cells. TdT-positive cells may occasionally be found in tonsils, lymph nodes and extranodal lymphoid tissue. Immunohistochemical detection of TdT has value in classification of malignant lymphomas and acute leukemias, particularly for the identification of pre-B and pre-T acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL).

UniProt: P04053

Pathways: Réparation de l'ADN