FYCO1 anticorps (AA 1-1019)

N° du produit ABIN7867920

L’anticorps anti-FYCO1 Polyclonal Lapin est utilisé pour la détection de FYCO1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA, IHC et FACS.

Aperçu rapide pour FYCO1 anticorps (AA 1-1019) (ABIN7867920)

Antigène: FYCO1 (FYVE and Coiled-Coil Domain Containing 1 (FYCO1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FYCO1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-FYCO1 anticorps

Épitope: AA 1-1019

Fonction: FYCO1 Antibody / FYVE and coiled-coil domain containing 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human FYCO1 recombinant protein (Position: M1-K1019) was used as the immunogen for the FYCO1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the FYCO1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the FYCO1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur FYCO1

Antigène: FYCO1 (FYVE and Coiled-Coil Domain Containing 1 (FYCO1))

Autre désignation: FYCO1

Sujet: FYCO1 antibody detects FYVE and coiled-coil domain containing 1, encoded by the FYCO1 gene. FYVE and coiled-coil domain containing 1 is a cytoplasmic protein that functions as an autophagy adaptor, linking autophagosomes to microtubule-based transport systems. FYCO1 antibody provides researchers with a key reagent for studying autophagy, vesicle trafficking, and disease mechanisms involving impaired cellular clearance.

FYVE and coiled-coil domain containing 1 contains a FYVE domain that binds phosphatidylinositol-3-phosphate on autophagosome membranes and a LC3-interacting region that recruits autophagy machinery. Research using FYCO1 antibody has shown that the protein couples autophagosomes to kinesin motors, promoting their transport along microtubules toward the cell periphery. This process facilitates autophagosome maturation and fusion with lysosomes.

Studies with FYCO1 antibody have revealed that loss-of-function mutations in FYCO1 cause autosomal recessive congenital cataracts. In lens epithelial cells, defective autophagy due to impaired FYCO1 activity leads to accumulation of damaged proteins and organelles, resulting in lens opacity. This genetic association highlights the clinical relevance of FYCO1 in ocular development and disease.

Dysregulation of FYVE and coiled-coil domain containing 1 has also been implicated in neurodegeneration and infection. Research using FYCO1 antibody has shown that altered expression affects autophagosome trafficking in neurons, contributing to accumulation of aggregates in neurodegenerative conditions. Pathogens such as Mycobacterium tuberculosis can manipulate FYCO1-mediated pathways, underscoring its significance in host-pathogen interactions.

FYCO1 antibody is widely applied in immunofluorescence, immunohistochemistry, and western blotting. Immunofluorescence highlights co-localization with LC3-positive autophagosomes, immunohistochemistry demonstrates tissue-specific expression, and western blotting quantifies levels in cells and tissues. These applications make FYCO1 antibody indispensable in autophagy and vesicle transport research.

By providing validated FYCO1 antibody reagents, NSJ Bioreagents supports studies into autophagy, cellular clearance, and disease. Detection of FYVE and coiled-coil domain containing 1 provides researchers with insight into how adaptor proteins regulate vesicle trafficking and pathology.

UniProt: Q9BQS8

Pathways: SARS-CoV-2 Protein Interactome