LMO2 anticorps (AA 1-159)

N° du produit ABIN7868222

Cet anticorps Lapin Polyclonal détecte spécifiquement LMO2 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour LMO2 anticorps (AA 1-159) (ABIN7868222)

Antigène: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LMO2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-LMO2 anticorps

Épitope: AA 1-159

Fonction: Danre Lmo2 Antibody / Rhombotin 2

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived Danre Lmo2 recombinant protein (amino acids M1-V159) was used as the immunogen for the Danre Lmo2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Danre Lmo2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Danre Lmo2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur LMO2

Antigène: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Autre désignation: Lmo2

Sujet: Lmo2, or LIM domain only protein two, is a transcriptional regulator that plays a critical role in hematopoietic and vascular development. In zebrafish, Lmo2 is essential for the specification of blood and endothelial lineages and is widely used as a molecular marker for early hematopoietic progenitor cells.

Lmo2 does not directly bind to DNA but functions as a scaffold protein, forming complexes with other transcription factors to regulate gene expression. During zebrafish embryogenesis, Lmo2 is expressed in the intermediate cell mass, the site of primitive blood cell formation, and in the developing vasculature. It is required for the emergence of both erythroid and myeloid lineages, as well as for the proper development of endothelial cells.

Loss of Lmo2 function in zebrafish results in severe defects in blood cell formation and vascular patterning, highlighting its central role in mesodermal differentiation. Because of its strong evolutionary conservation and defined expression patterns, zebrafish Lmo2 serves as a powerful model for studying hematopoiesis, angiogenesis, and transcriptional networks involved in early development.

Lmo2 is also relevant to human health, as misregulation of Lmo2 has been associated with leukemia. This makes zebrafish Lmo2 a valuable tool in both basic research and disease modeling related to blood development and cancer biology.

UniProt: Q9PTJ3

Pathways: Chromatin Binding